Sports anaemia, regulation of erythropoietin biosynthesis during physical effort and EPO doping

The regulation of heme biosynthesis during erythropoietin-induced erythroid differentiation.

Marrow cells induced toward erythroid differentiation by treatment with erythropoietin respond by increasing the rates of iron uptake and hemoglobin synthesis. Study of the enzymes of heme biosynthesis during erythroid differentiation suggests that induction of heme synthesis in these cells is regulated by synthesis of porphobilinogen deaminase. The activities of delta-aminolevulinic acid synth...

Autocrine stimulation by erythropoietin (Epo) requires Epo secretion.

Erythropoietin (Epo) autocrine stimulation has been implicated in erythroblastic leukemia. To examine whether this stimulation could occur intracellularly, we developed Epo autocrine models of stimulation in the human pluripotent UT-7 cell line. Retroviral expression of Epo totally abolished the growth factor requirement of UT-7 cells. Autonomous proliferation was not cell density-dependent and...

Erythropoietin (EPO) in acute kidney injury

Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence, however, suggests that EPO has additional organ protective effects, which may be useful in the prevention or treatment of acute kidney injury. These protective mechanisms are multifactor...

Hemoglobin, Erythropoietin and Doping testing

Erythropoietin – Blood Doping